LOSARTAN and HYDROCHLOROTHIAZIDE - HYZAAR ® COMMON USES: The combination of losartan and hydrochlorothiazide is used to treat high blood pressure. Losartan is in a class of medications called angiotensin II receptor antagonists. It works by blocking the action of certain chemicals that tighten the blood vessels, so blood flows more smoothly. Hydrochlorothiazide is in a class of medications called diuretics ('water pills'). It works by causing the kidneys to get rid of unneeded water and salt from the body into the urine. The combination of losartan and hydrochlorothiazide comes as a tablet to take by mouth. It is usually taken once a day with or without food. To help you remember to take losartan and hydrochlorothiazide, take it around the same time every day. Follow the directions on your prescription label carefully, and ask your doctor or pharmacist to explain any part you do not understand. Take losartan and hydrochlorothiazide exactly as directed. Do not take more or less of it or take it more often than prescribed by your doctor. Losartan and hydrochlorothiazide controls high blood pressure but does not cure it. Continue to take losartan and hydrochlorothiazide even if you feel well. Do not stop taking losartan and hydrochlorothiazide without talking to your doctor. This medication may be prescribed for other uses; ask your doctor or pharmacist for more information. Dietary Instructions: Talk to your doctor before using salt substitutes containing potassium. If your doctor prescribes a low-salt or low-sodium diet or an exercise program, follow these directions carefully. Storage Conditions: Keep this medication in the container it came in, tightly closed, and out of reach of children. Store it at room temperature and away from excess heat and moisture (not in the bathroom). Throw away any medication that is outdated or no longer needed.